Mikrobiol. Z. 2019; 81(6):110-130. Ukrainian.
doi: https://doi.org/10.15407/microbiolj81.06.110
Integrated Technologies of Microbial Synthesis of Several Final Products
Pirog T.P.1,2, Kliuchka L.V.1, Klymenko N.O.1, Shevchuk T.A.2, Iutynska G.O.2
1National University of Food Technologies
68 Volodymyrska Str., Kyiv, 01601, Ukraine
2Zabolotny Institute of Microbiology and Virology, NAS of Ukraine
154 Akad. Zabolotny Str., Kyiv, 03143, Ukraine
In recent years, the interest of researchers to the technology of microbial synthesis of final multifunctional products, in particular, polyhydroxyalkanoates and surfactants, has increased. However, their industrial production is limited by high costs of the biosynthesis process. One of the approaches to solving this problem is the implementation of so-called integrated biotechnologies, in which simultaneously with the final product, practically valuable metabolites are synthesized, the high market value of which allows reduce the cost of obtaining the final product. The review contains literature data on the simultaneous microbial synthesis of polyhydroxyalkanoates, surfactants, pigments, enzymes, organic acids, exopolysaccharides, amino- and polyaminoacids, phytohormones and bacteriocins. The applications of the complex of practically important metabolites with different properties synthesized by one producer are much wider than monopreparations. Different localization of several metabolites (intracellular and extracellular) synthesized on inexpensive and available in large quantities industrial waste allows to realize of highly efficient wastefree biotechnology.
Keywords: simultaneous synthesis of several products, final metabolite, byproduct, microbial technologies.
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