Mikrobiol. Z. 2017; 79(5):70-79. Ukrainian.
doi: https://doi.org/10.15407/microbiolj79.05.070

Patterns of Herpetic Infection Reactivation in The Liver

Motorna N.V.1, Rybalko S.L.2, Sokurenko L.M.1, Starosyla D.B.2, Savosko S.I.1, Chaikovsky Yu.B.1

1Bogomolets National Medical University
13 Shevchenko Blvd., Kyiv, 01601, Ukraine

2Gromashevsky Institute of Epidemiology and Infection Diseases, NAMS of Ukraine
5 Amosov Str., Kyiv, 03680, Ukraine

Herpes simplex virus (HSV) infection is quite prevalent in general population. However, the question of herpetic damage of the liver remains open. The present study aimed at identifying patterns of structural changes in the liver associated with acute and latent herpes virus infection and stroke-induced reactivation of the latter in mice.
Experimental results confrmed herpetic liver damage and post-stroke reactivation of viral infection in animals-carriers of latent infection. Our study demonstrated morphological and morphometric features of the hepatocytes regeneration, which coincide with the viral titer decrease in serum and tissue samples studied. The patterns of herpetic liver infection are characterized by the absence of tissue basophils response and their absence in the stroma as well as by the delayed process of fbrosis.

Key words: herpes simplex virus type I, liver, stroke, reactivation of the virus.

Full text (PDF, in Ukrainian)

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