Mikrobiol. Z. 2017; 79(1):66-75.
doi: https://doi.org/10.15407/microbiolj79.01.066

Immunobiotics are the Novel Biotech Drugs with Antibacterial and Immunomodulatory Properties

Lazarenko L.M.1, Babenko L.P.1, Bubnov R.V.1, Demchenko O.M.1, Zotsenko V.M.1, Boyko N.V.2, Spivak M.Ya.1,3

1Zabolotny Institute of Microbiology and Virology, NAS of Ukraine
154 Akad. Zabolotny Str., Kyiv, 03143, Ukraine

2Uzhhorod State University
46 Pidgirna Str., Uzhhorod, 88000, Ukraine

3LCL Diaprof
35 Svetlichnogo Str., Kyiv, 04123, Ukraine

This contribution deals with recently developed technology to obtain the novel biotech probiotic drugs on the basis of pre-selected and characterized strains of lactobacilli and bifidobacteria, which have antibacterial action and high level of ability to balance the immune response in infectious and infammatory diseases of bacterial, viral and fungal origin by induction of various cytokines. We created an experimental model for the study of immunomodulatory activity of probiotic strains of lactobacilli and bifidobacteria in vitro and in vivo. We esteblished that the probiotic strains Lactobacillus acidophilus IMV B-7279, L. casei IMV B-7280, Bifidobacterium animalis VKL and B. animalis VKВ, as well as different compositions based on probiotic strains might be promising for creating high-effective immune biotics with antibacterial and immune modulatory effects for treatments of infectious-and infammatory diseases, caused by pathogenic and opportunistic microorganisms.

Key words: lactobacilli, bifidobacteria, immunity, infection, diseases, biotech drugse.

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